The seed of University of Agricultural Sciences Bangalore was shown back in 1899 when Her Excellency Maharani Kempa Nanjammanni Vani Vilasa Sannidhi the Regent of Mysore donated 30 acres of land for Experimental Agricultural Station at Hebbal. German Scientist Dr Lehmann was appointed to instigate research on soil crop response with Laboratory in the Directorate of Agriculture. Later in 1906, Dr Leslie Coleman, Canadian Entolomologist and Mycologist succeeded Dr Lehmann and served with missionary enthusiasm for 25 years. By the time this experimental station was allotted 202 acres of land with 30 acres of wetland.

In 1913, Sir M Vishveshwaraiah, the then Diwan of Mysore (1912-1919) played the vital role in launching the Mysore Agriculture residential School. Dr Leslie Coleman was appointed the first Director. In 1946: Mr MA Srinivasan, Minister of Agriculture, took steps to put in place Agriculture College, Hebbal, for offering four year professional degree program in Agriculture affiliated to the University of Mysore. In 1956, Sri Kengal Hanumanthaiah, the Chief Minister, decided to build a new building for Agriculture College, and laid the Foundation Stone on 25 January 1956.

In 1961, the Government of India constituted Agricultural University Committee. Dr Ralph Cummings of Rockefeller Foundation was appointed the Head of the Committee. In June 1961, the committee submitted a favorable report for formation of Agricultural University at Hebbal. In 1963, Government of Mysore headed by Sri S Nijalingappa, the then Chief Minister decided to establish University of Agricultural Sciences (UAS) in the lines of Land Grant College system of USA and passed the University of Agricultural Sciences Bill (Act No. 22) which received assent of the President of India on 25th May 1963 to become the Law. The CM granted 1300 acres to Gandhi Krishi Vigjana Kendra Campus. Dr Zakir Hussain, the Vice President of India on The 21st Aug 1964, inaugurated the UAS.